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Protein Biochemistry
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ABT-888 (hydrochloride)
ABT-888 (hydrochloride) from Cayman Chemical
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Citations:
(3)
Supplier Page
Supplier Page from
Cayman Chemical for
ABT-888 (hydrochloride)
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Description
An orally bioavailable inhibitor of PARP1 and PARP2 (Kis = 5.2 and 2.9 nM, respectively); enhances apoptosis and autophagy in response to treatments that cause DNA breaks, including radiation and DNA alkylation
Product Specs
Company Info
Citations
Reviews
Product Specs
Item
ABT-888 (hydrochloride)
Company
Cayman Chemical
Price
Pricing Info
Supplier Page
View Company Product Page
Catalog Number
11505
Format
A crystalline solid
Research Area
Apoptosis, Autophagy, Cancer, Cell Biology, Cell Death, DNA Damage and Repair, Endomembrane System & Vesicular Trafficking, PARP
Molecular Weight
317.2
Quantity
25 mg
Purity
≥98%
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Cayman Chemical
Cayman Chemical Company 1180 East Ellsworth Road
Ann Arbor
,
Michigan
48108
United States
Phone
: (800) 364-9897
(734) 971-3640
Company Profile
Website:
http://www.caymanchem.com/
Citations (3)
(1)
Captured snapshots of PARP1 in the active state reveal the mechanics of PARP1 allostery
Molecular Cell
August 1, 2022
Élise Rouleau-Turcotte, Dragomir B. Krastev, Stephen J. Pettitt, Christopher J. Lord, John M. Pascal
,
Cayman Chemical
,Cat#
34684
Talazoparib,
SelleckChem
,Cat#
S7048
"
Veliparib (ABT-888
, hydrochloride)",
Cayman Chemical
,Cat#
11505
Hydroxylamine (NH2OH),Sigma-Aldrich,Cat#467804 ,, Critical commercial
assays
,Critical commercial
(2)
A system-level approach identifies HIF-2α as a critical regulator of chondrosarcoma progression
Nature communications
October 6, 2020
Kim H, Cho Y, Kim HS, Kang D, Cheon D, Kim YJ, Chang MJ, Lee KM, Chang CB, Kang SB,
et al
.
were purchased from
Sigma Aldrich
. The mutant IDH
inhibitor
AG-881 (cat. No.
28462
), ABT-888 (cat. No.
11505
) and doxorubicin (cat. No.
15007
) were purchased from
Cayman
. MG132 (A2585) were purchased from Apexbio.
(3)
Tankyrase inhibition preserves osteoarthritic cartilage by coordinating cartilage matrix anabolism via effects on SOX9 PARylation
Nature communications
October 25, 2019
Kim S, Han S, Kim Y, Kim HS, Gu YR, Kang D, Cho Y, Kim H, Lee J, Seo Y,
et al
.
inhibitors
were classified into three different classes depending on their mode of action24,88. ABT-888 (
11505
) was purchased from
Cayman
, and ADP–HPD (118415) was purchased from Calbiochem.
RNA sequencing
(
RNA-seq
) Primary
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ABT-888 (hydrochloride) from Cayman Chemical
Supplier Page
View Company Product Page
Pricing Info
Product Specs
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